INHIBITION OF DAI REFRAINS DENDRITIC CELLS FROM MATURATION AND PROLONGS MURINE ISLET AND SKIN ALLOGRAFT SURVIVAL

Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival

IntroductionCentral to allograft rejection is the T cell-mediated adaptive immune response initiated by activated dendritic cells (DCs).Previous studies have shown that the DNA-dependent activator of IFN regulatory factors (DAI) is involved in the maturation and activation of DCs.Therefore, we hypothesized that inhibition of DAI could prevent DCs f

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Topical therapies of pyogenic granuloma in children: A systematic review of case reports, case series, and cohort studies

Pyogenic granuloma (PG) is a benign vascular tumor removed surgically or by physical modalities, such as electrocautery and cryotherapy.Other treatment options may be warranted, especially in children, using nonsurgical approach.The study aims to determine the effectiveness and safety of topical treatments on PG in children in the clearance of lesi

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Inhibition of Metastatic Hepatocarcinoma by Combined Chemotherapy with Silencing VEGF/VEGFR2 Genes through a GalNAc-Modified Integrated Therapeutic System

Hepatocellular carcinoma (HCC) is a highly malignant tumor related to high mortality and is still lacking a satisfactory cure.Tumor metastasis is currently a major challenge of cancer treatment, which is highly related to angiogenesis.The vascular endothelial growth factor (VEGF)/VEGFR signaling pathway is thus becoming an attractive therapeutic ta

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