Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival
IntroductionCentral to allograft rejection is the T cell-mediated adaptive immune response initiated by activated dendritic cells (DCs).Previous studies have shown that the DNA-dependent activator of IFN regulatory factors (DAI) is involved in the maturation and activation of DCs.Therefore, we hypothesized that inhibition of DAI could prevent DCs f